Altered microRNA expression associated with chromosomal changes contributes to cervical carcinogenesis
نویسندگان
چکیده
منابع مشابه
MicroRNA-126 Inhibits SOX2 Expression and Contributes to Gastric Carcinogenesis
BACKGROUND SRY (sex-determining region Y)-box 2 (SOX2) is a crucial transcription factor for the maintenance of embryonic stem cell pluripotency and the determination of cell fate. Previously, we demonstrated that SOX2 plays important roles in growth inhibition through cell cycle arrest and apoptosis, and that SOX2 expression is frequently down-regulated in gastric cancers. However, the mechani...
متن کاملAltered MicroRNA expression in cervical carcinomas.
PURPOSE MicroRNAs (miRNA) are small noncoding RNAs that are 18 to 25 nucleotides in length; they regulate the stability or translational efficiency of target mRNAs. Emerging evidence suggests that miRNAs might be involved in the pathogenesis of a variety of human cancers. EXPERIMENTAL DESIGN In this study, we profiled miRNA expression in 10 early stage invasive squamous cell carcinomas (ISCC)...
متن کاملAltered Gene Expression Associated with microRNA Binding Site Polymorphisms
Allele-specific gene expression associated with genetic variation in regulatory regions can play an important role in the development of complex traits. We hypothesized that polymorphisms in microRNA (miRNA) response elements (MRE-SNPs) that either disrupt a miRNA binding site or create a new miRNA binding site can affect the allele-specific expression of target genes. By integrating public exp...
متن کاملChromosomal changes associated with changes in development.
In the past there has been a tendency to dwell on aspects of chromosomes which stress constancy of structure, number and content; even to the extent of dismissing exceptions as 'aberrations' or 'oddities'. It is now becoming clear that genomes can be quite plastic, and that structural changes to chromosomes are an important and often necessary part of normal differentiation and development. Eli...
متن کاملTetraploidy and chromosomal instability are early events during cervical carcinogenesis.
Chromosomal instability as manifested by increases in aneuploidy and structural chromosome aberrations is believed to play a critical role in the intermediate to late stages in the development of cervical malignancies. The current study was designed to determine the role of tetraploidy in the formation of aneuploidy and ascertain the occurrence of these alterations during the earlier stages of ...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2012
ISSN: 0950-9232,1476-5594
DOI: 10.1038/onc.2012.20